Antibiotic Resistance In today's blog, we will try to answer the question on antibiotics resistance, and with it, we will also be discussing combination therapy and its related complications. So, what is resistance? According to WHO drug resistance is a state of insensitivity and it refers to the unresponsiveness of microorganisms to an Antibiotic. Now, the question is when does a microbe become resistant? Antibiotic resistance happens when the microbes no longer react to the antibiotics. They continuously grow by developing an ability to defeat the drugs built to kill them. Have you ever wondered why? causes of resistance Some organisms are inherently resistant to antibiotics. However microbial species that are generally responsive to a specific drug may develop more virulent or resistant strains through spontaneous mutation or acquired resistance and selection. Some of these strains may even evolve resistant to more than one antibiotic. The different mechanisms by whi